Oscar winner George Clooney certainly has his fair share of female fans, but OK! has learned you probably shouldn’t count Jennifer Aniston among them!

The handsome Michael Clayton star — who just happens to be best buds with Jen’s ex Brad Pitt — sauntered up to the actress at last Saturday’s Night Before gala in Beverly Hills, where she was busy chatting with BFF Courteney Cox, David Arquette, Orlando Bloom, Robert Downey Jr. and his wife, Susan, outside of Bar Nineteen12.

“George attempted to be friendly, but Jen wasn’t having it,” one eyewitness tells OK!. “After enduring a few minutes of the actor’s presence, Jen turned on her heels and made a beeline for the Sunset Ballroom, where most of the guests were mingling.”

Courteney, naturally, joined Jen, leaving her affable husband, David, to make awkward small talk with George!

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With best friends like Giorgio Armani and Victoria Beckham and big plans to have her own haute couture label in the future, it isn’t surprising that Katie Holmes is always among the most fashion-forward women in Hollywood.

But when the slender star showed up wearing loose-fitting dresses at both the Costume Designers Guild Awards and the Essence Black Women in Hollywood Awards that seemed to reveal the hint of a bump to spectators, the question on everyone’s lips was: Could Katie have a baby on board?

“She has that special glow that only pregnant women have,” an eyewitness tells OK!. “I would say there is a strong possibility that she’s pregnant.”

If the Mad Money star is expecting, the timing couldn’t be better, with little daughter Suri turning 2 in April. “Katie’s a big believer in big families and lots of siblings. It’s how she was brought up,” a Holmes family friend tells OK!. The 29-year-old actress has three older sisters and a brother eight years her senior. “She was always jealous of being so far apart in age from her siblings, so she doesn’t want to space it out too far.”

And with Katie’s next slated project, The Other Side, currently stalled, it has left her with time for another child. “To be honest, she’s giving up the pipe dream of wanting an Oscar for now,” the pal says. “She wants to focus on being married and happy, and giving Suri a little brother or sister.”

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Less than 24 hours after it was discovered that a deal had been hammered out between the lawyers in the Britney Spears vs. Kevin Federline custody case that would allow the pop star supervised visits with her children, the little Federline lads came to pay mom a visit at her L.A. home.

Around 9 a.m. PT on Saturday, a Dodge truck carrying Sean Preston, 2, and 1-year-old Jayden James entered Britney’s gated community, The Summit.

By noon, the boys were on their way back home to K-Fed. “They definitely had smiles on their faces after the visit,” one witness tells OK!.

Also inside the house during the visit were Brit’s father, Jamie Spears, a psychologist, one of Kevin’s bodyguard, the court-ordered monitor, and a lawyer. According to a source, the pop singer was not allowed to leave the common area of the house, where Jamie and the others could supervise, without the children.

This was the first time the boys have seen their mother since the Jan. 3 standoff with authorities that landed Britney in the hospital for several nights. Until this visit, she had only been allowed to speak with her children during short phone conversations.

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Given that Jessica Simpson’s life was turned upside down by her experience with ex-husband Nick Lachey on their hit MTV show Newlyweds, it came as a big surprise when her father and manager Joe Simpson told Entertainment Weekly earlier this week that Jess is considering giving reality TV another shot with an unscripted show on CMT.

“With Newlyweds, she let everyone into her world,” Joe told EW.com. “Then she had to shut the world out. Now she can open it up again so people can see, here’s a girl struggling with self-esteem and finding her way.”

However, a rep for the Employee of the Month actress tells OK!, “She is in talks to do a special for CMT timed to the release of the album, but there’s no truth to any reality show.” And a rep for Sony BMG Nashville confirms to OK!, “there is no truth to this.”

So was Joe misleading the folks at EW? Or did he sign his daughter up for something without telling her?

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For actor Eric Dane, the first sign that something was wrong came right after the new year, when the Grey’s Anatomy star glanced in the mirror and saw what looked like chapped lips but clearly wasn’t.

“I went to my dermatologist,” Eric reveals in an exclusive interview in the new issue of OK!. But the last thing the 35-year-old expected was to be diagnosed with skin cancer. “He said it was malignant tissue caused by sun damage.”

The malignancy was treated by freezing the cancerous tissue off with liquid nitrogen. Unfortunately for Eric, the actor had a severe reaction to a cream given to him for his lip after the treatment . “My skin is very sensitive,” the actor most famous for playing Dr. Mark “McSteamy” Sloan, explains to OK!, “and my lip was traumatized by the procedure I had to go through.”

His lip’s overreaction to the medication created a painful scenario that made eating difficult, if not impossible. “I didn’t eat very well for a couple of weeks and lost a bunch of weight,” Eric explains, estimating that he dropped at least 10 pounds off his 6′1″ frame while dealing with his cancer.

“Skin cancer is the most common form of cancer in the United States,” Dr. Micki Ly, a Maui, Hawaii-based dermatologist, explains to OK!. “More than a million cases are diagnosed annually.” But Eric was extremely wise to act quickly in dealing with it, she says. “The mouth is a bad area for a malignancy because they spread faster in mucosal areas, of which the mouth is one.”

For the complete interview with Eric — including how this cancer scare impacted his relationship with wife, actress Rebecca Gayheart — pick up the new issue of OK!, on sale everywhere Thursday.

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